Publikationen

Wissenschaftliche Veröffentlichungen (Originalarbeiten)

  • Toenges G, Muetze T, Jahn-Eimermacher A. A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials. Stat Med 2021. doi: 10.1002/sim.9149
  • Wei J, Muetze T, Jahn-Eimermacher A, Roger J. Properties of two while-alive estimands for recurrent events and their potential estimators. Statistics in Biopharmaceutical Research 2021. doi: 10.1080/19466315.2021.1994457
  • Miltenberger R, Götte H, Schüler A, Jahn-Eimermacher A. Progression-free survival in oncological clinical studies: Assessment time bias and methods for its correction. Pharmaceutical Statistics 2021; doi: 10.1002/pst.2115
  • Fritsch A, Schlömer P, Mendolia F, Mütze T, Jahn-Eimermacher A & on behalf of the Recurrent Event Qualification Opinion Consortium . Efficiency Compar ison of Analysis Methods for Recurrent Event and Time -to-First Event Endpoints in the Presence of Terminal Events - Application to Clinical Trials in Chronic Heart Failure. Statistics in Biopharmaceutical Research 2021; doi: 10.1080/19466315.2021.1945488
  • Toenges G, Jahn-Eimermacher A. Computational issues in fitting joint frailty models for recurrent events with an associated terminal event. Computer Methods and Programs in Biomedicine 2020; doi: 10.1016/j.cmpb.2019.105259
  • Toenges G, Jahn-Eimermacher A. Marginal hazard ratio estimates in joint frailty models for heart failure trials. Biometrical Journal 2019;61:1385–1401.
  • Uphaus T, Weber-Krüger M, Grond M, Toenges G, Jahn-Eimermacher A, Jauss M, Kirchhof P, Wachter R, Gröschel K. Development and validation of a score to detect paroxysmal atrial fibrillation after stroke. Neurology. 2019;92:e115-e124.
  • Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Luk as C, Gold R, Lill CM, Zipp F. Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Mult Scler. 2019;25:661-668.
  • Rauch G, Kieser M, Binder H, Bayes -Genis A, Jahn-Eimermacher A. Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints. Clin Res Cardiol. 2018;107:437-443.
  • Jahn-Eimermacher A, Ingel K, Preussler S, Bayes -Genis A, Binder H. A DAG -based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials. BMC Med Res Methodol. 2017;17:92.
  • Kamuf J, Garcia-Bardon A, Duenges B, Liu T, Jahn-Eimermacher A, Heid F, David M, Hartmann EK. Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs. Respir Res. 2017;18:101.
  • Ott T, Barth A, Kriege M, Jahn-Eimermacher A, Piepho T, Noppens RR. The novel video-assisted intubating laryngeal mask Totaltrack compared to the intubating laryngeal mask Fastrach - a controlled randomized manikin study. Acta Anaesthesiol Scand. 2017; 61: 381-389
  • Sebastiani A, Hirnet T, Jahn-Eimermacher A, Thal SC. Comparison of speed-vacuum method and heat-drying method to measure brain water content of small brain sample. J Neurosci Methods 2017; 276:73-78.
  • Limbach T, Ott T, Griesinger J, Jahn-Eimermacher A, Piepho T. Bonfils intubation fibrescope: use in simulation-based intubation training for medical students in comparison to MacIntosh laryngoscope. BMC Res Notes 2016; 9:127
  • Jahn-Eimermacher A, Ingel K, Ozga AK, Preussler S, Binder H. Simulating recurrent event data with hazard functions defined on a total time scale. BMC Medical Research Methodology 2015; 15:16.
  • Karbach J, Hartmann S, Jahn-Eimermacher A, Wagner W. Prospective randomised cross-over study for the oral health related quality of life in mandibular edentulous patients with a two versus four locator- retained overdenture. International Journal of Oral and Maxillofacial Implants 2015; 30:1143-8.
  • Wang J, Jahn-Eimermacher A, Brückner M, Werner C, Engelhard K, Thal SC. Comparison of different quantification methods to determine hippocampal damage after cerebral ischemia. Journal of Neuroscience Methods 2015; 240:67-76.
  • Rey JW, Jahn-Eimermacher A, Doernberger V, Barreiros AP, Krupp M, Hoffman A, Kiesslich R, Müller-Schilling M, Galle PR, Teufel A. To biopsy or not to biopsy: evaluation of a large German cohort of patients with abnormal liver tests of unknown etiology. Digestion 2014; 89:310-8.
  • Rauch G, Jahn-Eimermacher A, Brannath W, Kieser M. Opportunities and challenge s of combined effect measures based on prioritized outcomes. Statistics in Medicine 2014; 33: 1104-20.
  • Ingel K, Jahn-Eimermacher A. Sample-size calculation and reestimation for a semiparametric analysis of recurrent event data taking robust standard errors into account. Biometrical Journal 2014; 56:631-48.
  • Jahn-Eimermacher A, Ingel K, Schneider A. Sample size in cluster-randomized trials with time to event as the primary endpoint. Stat Med 2013; 32: 739-51.
  • Schaible EV, Steinsträßer A, Jahn-Eimermacher A, Luh C, Sebastiani A, Kornes F, Pieter D, Schäfer MK, Engelhard K, Thal SC. Single administration of tripeptide α -MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice. PLoS One 2013; 8:e71056.
  • Brückner M, Lasarzik I, Jahn-Eimermacher A, Peetz D, Werner C, Engelhard K, Thal SC. High dose infusion of activated protein C (rhAPC) fails to improve neuronal damage and cognitive deficit after global cerebral ischemia in rats. Neuroscience Letters 2013; 551:28-33.
  • Jahn-Eimermacher A, Lasarzik I, Raber J. Statistical analysis of latency outcomes in behavioral experiments. Behavioural Brain Research 2011; 221: 271-275.
  • Mordhorst C, Latz B, Kerz T, Wisser G, Schmidt A, Schneider A, Jahn-Eimermacher A, Werner C, Engelhard K. Prospective assessment of postoperative pain after craniotomy. Journal of Neurosurgical Anesthesiology 2010; 22:202-6.
  • Koch FP, Weng D, Krämer S, Biesterfeld S, Jahn-Eimermacher A, Wagner W. Osseointegration of o ne-piece zirconia implants compared with a titanium implant of identical design: a histomorphometric study in the dog. Clinical Oral Implants Research 2010; 21:350-6.
  • Jahn-Eimermacher A, Ingel K. Adaptive trial design: a general methodology for censored time to event data. Contemporary Clinical Trials 2009; 30: 171-177.
  • Moergel M, Jahn-Eimermacher A, Krummenauer F, Reichert TE, Wagner W, Wendt TG, Werner JA, Al-Nawas B. Effectiveness of adjuvant radiotherapy in patients with oropharyngeal and floor of mouth squamous cell carcinoma and concomitant histological verification of singular ipsilateral cervical lymph node metastasis (pN1 -state)--a prospective multicenter randomized controlled clinical trial using a comprehensive cohort design. Trials 2009; 10:118.
  • Lasarzik I, Winkelheide U, Thal SC, Benz N, Lörscher M, Jahn-Eimermacher A, Werner C, Engelhard K. Mild hypothermia has no long-term impact on postischemic neurogenesis in rats. Anesthesia & Analgesia 2009; 109:1632-9.
  • Huebner G, Link H, Kohne CH, Stahl M, Kretzschmar A, Steinbach S, Folprecht G, Bernhard H, Al-Batran SE, Schoffski P, Burkart C, Kullmann F, Otremba B, Menges M, Hoffmann M, Kaiser U, Aldaoud A, Jahn A ; German CUP Study Group. Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno - or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial. British Journal of Cancer 2009; 100:44-9.
  • Jahn-Eimermacher A. Comparison of the Andersen-Gill model with poisson and negative binomial regression on recurrent event data. Computational Statistics and Data Analysis, 2008; 52: 4989-4997.
  • Jahn-Eimermacher A, Hommel G. Performance of adaptive sample size adjustment with respect to stopping criteria and time of interim analysis. Stat Med 2007; 26: 1450-61.
  • Jahn-Eimermacher A, duPrel JB, Schmitt HJ. Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Vaccine 2007; 25: 6237-44.
  • Moehler M, Eimermacher A, Siebler J, Höhler T, Wein A, Menges M, Flieger D, Junginger T, Geer T, Gracien E, Galle PR, Heike M. Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF) vs 5-fluorouracil, leucovorin, and etoposide (ELF) in untreated metastatic gastric cancer. British Journal of Cancer 2005; 92:2122-8.
  • Schlitt A, von Bardeleben RS, Ehrlich A, Eimermacher A, Peetz D, Dahm M, Rupprecht HJ. Clopidogrel and aspirin in the prevention of thromboembolic complications after mechanical aortic valve replacement (CAPTA). Thrombosis Research 2003; 109:131-5.

Verzeichnis der wissenschaftlichen Vorträge

  • Jahrestagung der Sektion Östereich/Schweiz der internationalen Biometrischen Gesellschaft, Salzburg (2021): A Comparison of Semiparametric Approaches to Evaluate Composite Endpoints in Heart Failure Trials
  • Jahrestagung der PSI, Amsterdam (2018): Association between hospitalisation and mortality rates in heart failure trials: Consequences for marginal treatment effect estimates (Invited)
  • Jahrestagung der International Society for Clinical Biostatistics (2017). Simulating Recurrent Event Data with a Calendar Time Scale (Invited)
  • Jahrestagung der International Society for Clinical Biostatistics, Birmingham (2016): Motivating multistate modeling of recurrent composite endpoints in randomized cardiovascular trials via bias analyses with directed acyclic graphs
  • Tagung der Deutschen Arbeitsgemeinschaft Statistik, Göttingen (2016): Multistate and joint modeling of recurrent hospitalizations and mortality in clinical trials: consequences on effect estimation and power
  • Kolloquium „Medizinische Biometrie, Informatik und Epidemiologie“, Heidelberg (2016): Multiplicity in multistate models for recurrent hospitalizations and death (Invited)
  • Kolloquium „Statistische Methoden in der empirischen Forschung“, Berlin (2015): Analyse rekurrenter Hospitalisierungen und Tod: von zusammengesetzten Endpunkten zu Mehrstadienmodellen (Invited)
  • Adaptive Designs and Multiple Comparison Procedures Workshop, Köln (2015): Multiplicity issues in multistate models for recurrent event data subject to a competing terminal event with an application to cardiovascular disease
  • 61. Biometrisches Kolloquium, Dortmund (2015): Simulating recurrent event data in the presence of a competing terminal event with an application to cardiovascular disease
  • Jahrestagung der International Society for Clinical Biostatistics, Wien (2014): A total time approach for the simulation of recurrent event data when planning a clinical trial
  • Joint Statistical Meeting Deutsche Arbeitsgemeinschaft Statistik, Freiburg (2013): Resampling validation of a sample size formula for clustered time to event data
  • Kolloquium des Instituts für Medizinische Biometrie und Informatik des Universitätsklinikums Heidelberg (2012): Sample size calculation in cluster randomized trials with a time to event outcome (Eingeladener Vortrag)
  • Joint Statistical Meeting, San Diego (2012): Planning the sample size of a cluster randomized trial when the primary endpoint is a time to event
  • 2nd Conference of the Central European Network, Zürich (2011): Sample size calculation in cluster randomized trials with a time to event outcome
  • Gemeinsame Tagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) und der Deutschen Gesellschaft für Epidemiologie (DGEpi),  Mainz (2011): Überlebenszeitmodelle zur statistischen Auswertung von Labyrinthversuchen
  • Grand Round of the Department for Public Health and Preventive Medicine, Oregon Health & Science University, USA (2011): Statistical analysis of latency data in behavioral experiments (Eingeladener Vortrag)
  • 4th Seattle Symposium in Biostatistics: Clinical Trials, Seattle, USA (2010): Performance of frailty and robust survival methods in small sample sizes
  • Joint Statistical Meeting, Vancouver, Canada (2010): Sample size calculation for the Andersen-Gill model in the presence of subject heterogeneity in the baseline risk
  • Adaptive Design and Multiple Comparison Procedures Workshop, Warwick (2009): Adaptive designs for recurrent event data using the inverse normal method
  • Biometrisches Kolloquium, Hannover (2009): Adaptive Designs für Cox Regressionen unter Nutzung der Inverse Normal Methode
  • Kolloquium des Departments für Medizinische Biometrie und Medizinische Informatik des Universitätsklinikums Freiburg (2008): Statistical analysis of recurrent failure time data: Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children (Invited)
  • Kolloquium „Statistische Methoden in der empirischen Forschung“ des Instituts für Biometrie und Informationsverarbeitung der Freien Universität Berlin (2008): Auswertung rekurrenter Ereigniszeitdaten: Vergleich von Andersen-Gill mit Poisson- und Negative-Binomial-Regression an simulierten Daten (Invited)
  • Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Stuttgart (2008): Ein adaptives Design für Überlebenszeitdaten unter Nutzung von Links-Trunkierung
  • Annual Workshop of the Working Group “Adaptive Designs and Multiple Testing Procedures”, Mainz (2008): An adaptive design for survival data using left-truncation
  • Statistik-Forum GlaxoSmithKline Biologicals Brüssel (2007): A comparison of the Andersen-Gill approach, poisson and negative binomial regression on simulated recurrent event data with intra-subject correlation (Invited)
  • Workshop: Statistische Methoden für korrelierte Daten, Bochum (2006): Comparison of the Poisson- and the Andersen-Gill-model on simulated recurrent event data with intra-subject correlation
  • Methodenseminar des Instituts für Medizinische Informatik und Biomathematik des Universitätsklinikums Münster (2005): Modellierung von Überlebenszeitdaten bei rekurrenten Ereignissen (Invited)
  • Kolloquium der Deutschen Region der Internationalen Biometrischen Gesellschaft, Halle (2005): Modeling survival data: An application to recurrent failure time data with event-specific baseline hazards
  • Workshop: Adaptiv-sequentielle Verfahren, Mainz (2004): Optimale Fallzahlfunktionen
  • Gemeinsame Tagung der Deutschen Region der Internationalen Biometrischen Gesellschaft und der Deutschen Arbeitsgemeinschaft für Epidemiologie, Heidelberg (2004): Risks and benefits of sample size adjustments
  • Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Köln (2001): A flexible tool for generating randomization schedules
  • Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), Berlin (2002): Development of SAS-macros for standardized analyses of clinical trials

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